These mice — free of pain-incited unpleasantness — skittered within the outer regions, undeterred by the intense temperatures. It's important to point out that (one) there could be pain with no activity in Key afferent nociceptors, and (2) there is often activity in Principal afferent nociceptors with no pain. https://www.proleviate.com/post/conolidine-blocks-ackr3-pain-receptors-in-what-way