Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals with the microenvironment and growing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have determined recurrent mutations in genes regulating tumor cell-microenvironment interactions, th... https://janeh207ajq4.laowaiblog.com/profile