In the LSD-bound crystal composition, the side chain of your lid residue L209EL2 kinds substantial hydrophobic contacts with both of those LSD and surrounding residues in TMs III, IV, and V (Determine 4C). If the lid moved aside to expose the binding pocket in simulation, many of such contacts broke. https://eduardojwbrg.estate-blog.com/34213061/what-does-lsd-vial-mean